A CONVENIENT AND NEW ONE-STEP SYNTHESIS OF 1H-IMIDAZOLE-2-CARBOXAMIDES

被引：1
|
作者：
SINGH, B
机构：
[1] Department of Medicinal Chemistry, Sterling Winthrop Pharmaceuticals Research Division, Rensselaer
来源：
HETEROCYCLES | 1992年 / 34卷 / 12期
关键词：
D O I：
10.3987/COM-92-6169
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
1,2-Diketone monophenylhydrazones (2) reacted with aminomalonamide in 1-methyl-2-pyrrolidinone to provide 1-H-imidazole-2-carboxamides (4). The condensation of 1-(4-pyridinyl)-2-propanone with phenyldiazonium chloride gave 1-phenylhydrazono-1-(4-pyridinyl)-2-propanone (2a). 4-Methyl-5-(4-pyridinyl)-1H-imidazole-2-carboxamide (4a) was converted to the corresponding nitrile (5a) by the action of phosphorous oxychloride.
引用
收藏
页码：2373 / 2378
页数：6
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