The Zoige Wetland National Nature Reserve is influenced by multiple factors, and the changes of holistic distribution and environment on the land cover are aggravating unceasingly. This paper is an integrated analysis include the spatial distribution pattern, rangeability, mainly changeable reasons of land cover types, and conditions of environment, which is made by tow images in 2010 and 2014 received by ZY-3 of China. Research finding as follow: First, the land cover type in reserve mainly made up of grasslands in 2010 and 2014, it covered over 95%, then the water wetlands, desert and bare grounds, forestland areas took second place. Second, because of over grazing, disasters of mouse and insects, traveling, medicine digging and so on, land cover types in reserve transferred more frequently, especially among grasslands, desert and bare grounds and water wetlands. Compared with 2010, grasslands are decreasing, while the desert and bare grounds, forestlands and building areas are increasing. Finally, at present, the per-capita ecological footprint is much smaller than per-capita ecological carrying capacity, and the development is in a relatively sustainable state.