COMPARATIVE HAEMOSTATIC EFFICACY OF SUCCULENT LEAF EXTRACTS AND LATEX OF SOME WOUND HEALING PLANTS ON FRESH WOUND OF RABBIT

Ethnomedicinal report of haemostatic activity of six medicinal plants was validated by a study of the effect of succulent leaf extract of plant parts on the punch wound of rabbit for the first time. It was found that the succulent leave extracts of Artemisia nilagirica (Clarke), Barleria lupulina Lindl., Blumea lacera Dc., Croton bonplandianum Baill, Glinus lotoides Lin. and Mikania scandens (L) Willd. can induce haemostasis in fresh wounds as compared to automatic haemostasis (120.00 +/- 2.91 seconds). The fresh leave extract of Mikania scandens took 25.00 +/- 1.87 seconds for haemostatic activity. Artemisia nilagirica (35.00 +/- 1.50 seconds), Barleria lupulina (30.00 +/- 2.34 seconds), Blumea lacera (38.00 +/- 1.87 seconds), Glinus lotoides (35.00 +/- 2.29 seconds) are having better action than Croton bonplandianum (leaf extract), which took 40.00 +/- 2.69 seconds time for haemostasis. The latex collected from the wounded small branches of living Croton bonplandianum plant is having highest efficacy in causing haemostasis (10.00 +/- 1.22 seconds), better than the positive control of Tincture Ferric per Chloride (13.00 +/- 2.54 seconds). The dermal toxicity study reveals that the application of the fresh plant extract on the skin of rat failed to produce any detrimental effect. The plant extracts collected from succulent plant leaves and particularly the latex collected from the living Croton bonplandianum Baill. plant can be used as haemostatic agents.