LIVE ATTENUATED PSEUDORABIES VIRUS EXPRESSING ENVELOPE GLYCOPROTEIN-E1 OF HOG-CHOLERA VIRUS PROTECTS SWINE AGAINST BOTH PSEUDORABIES AND HOG-CHOLERA

被引：206
|
作者：
VANZIJL, M
WENSVOORT, G
DEKLUYVER, E
HULST, M
VANDERGULDEN, H
GIELKENS, A
BERNS, A
MOORMANN, R
机构：
[1] CENT VET INST,DEPT VIROL,HOUTRIBWEG 39,8221 RA LELYSTAD,NETHERLANDS
[2] NETHERLANDS CANC INST,DIV MOLEC GENET,1066 CX AMSTERDAM,NETHERLANDS
[3] UNIV AMSTERDAM,DEPT BIOCHEM,AMSTERDAM,NETHERLANDS
来源：
JOURNAL OF VIROLOGY | 1991年 / 65卷 / 05期
关键词：
D O I：
10.1128/JVI.65.5.2761-2765.1991
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
To investigate whether live attenuated pseudorabies virus (PRV) can be used as a vaccine vector, PRV recombinants that expressed envelope glycoprotein E1 of hog cholera virus (HCV) were generated. Pigs inoculated with these recombinants developed high levels of neutralizing antibodies against PRV and HCV and were protected against both pseudorabies and hog cholera (classical swine fever).
引用
收藏
页码：2761 / 2765
页数：5
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