A KINETIC-ANALYSIS OF THE REPAIR OF RADIATION-INDUCED DNA DOUBLE-STRAND BREAKS

被引：4
|
作者：
TSENG, S [1 ]
HSU, JP [1 ]
机构：
[1] NATL TAIWAN UNIV,CHEM ENGN,TAIPEI 10764,TAIWAN
来源：
RADIATION RESEARCH | 1990年 / 122卷 / 03期
关键词：
D O I：
10.2307/3577764
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
The repair of radiation-induced DNA double-strand breaks (DSBs) is analyzed kinetically. It is assumed that a fraction of the damaged sites in the DNA duplex are irreparable. The kinetic model takes the effect of radiation dose into account. The analysis of the available experimental data reveals that, although the number of irreparable DSBs is a quadratic function of radiation dose, the normalized number of irreparable DSBs correlates linearly with this variable.
引用
收藏
页码：333 / 336
页数：4
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