MASS-PRODUCTION OF BIOSENSORS

被引:150
|
作者
ALVAREZICAZA, M
BILITEWSKI, U
机构
[1] Gesellschaft für Biotechnologische, Forschung mbH, Department of Enzyme Technology, D-W-3300 Braunschweig
关键词
D O I
10.1021/ac00059a001
中图分类号
O65 [分析化学];
学科分类号
070302 ; 081704 ;
摘要
As a result of the accomplishments in biosensor research over the past 30 years, it is simple to use immobilized enzymes to fabricate electrodes of various materials, sizes, and forms. In addition, scientists have a greater theoretical understanding of parameters such as enzyme activity and diffusion properties that influence sensor response. We have summarized the most important design parameters in Table III. We know which technologies (including membrane fabrication, screen printing, and photolithographic techniques such as thin-film methods) are, in principle, suitable for the mass production of enzyme electrodes. This knowledge has led to the commercialization of enzyme analyzers that are used mainly for glucose or lactate determination. But there are still many parameters that must be improved to achieve reproducible fabrication of sensors applicable to other fields. For example, the electron transfer between enzyme and electrode has to be improved before reagentless, implantable sensors can be fabricated. Another active area of research is in the development of easy-to-use small immunosensors. Commercialization of these devices will be achieved only when attention to their manufacturing aspects is accelerated. © 1993, American Chemical Society. All rights reserved.
引用
收藏
页码:A525 / A533
页数:9
相关论文
共 50 条
  • [1] MASS-PRODUCTION
    STEWART, DL
    [J]. JOURNAL OF THE KENTUCKY MEDICAL ASSOCIATION, 1982, 80 (01): : 29 - 29
  • [2] ART IN MASS-PRODUCTION
    DUBOVA, MM
    [J]. GLASS AND CERAMICS, 1978, 35 (1-2) : 58 - 60
  • [3] MASS-PRODUCTION WORK
    WILD, R
    [J]. JOURNAL OF GENERAL MANAGEMENT, 1976, 3 (03) : 30 - 40
  • [4] MASS-PRODUCTION OF INTERFERON
    不详
    [J]. EAST, 1980, 16 (3-4): : 55 - 55
  • [5] THE MASS-PRODUCTION OF KNOWLEDGE
    ZILSEL, PR
    [J]. BULLETIN OF THE ATOMIC SCIENTISTS, 1964, 20 (04) : 28 - 29
  • [6] CRISIS IN MASS-PRODUCTION
    WILD, R
    [J]. ENGINEERING, 1973, 213 (06): : 419 - 420
  • [7] PIONEER IN MASS-PRODUCTION
    不详
    [J]. WERKSTATTSTECHNIK ZEITSCHRIFT FUR INDUSTRIELLE FERTIGUNG, 1990, 80 (11): : 601 - 601
  • [8] Mass-production of microstructures
    Michaeli, W
    Rogalla, A
    Ziegmann, C
    [J]. KUNSTSTOFFE-PLAST EUROPE, 1999, 89 (09): : 80 - 82
  • [9] CONTROLLING MASS-PRODUCTION
    THOMPSON, D
    [J]. ENGINEERING, 1981, 221 (12): : 937 - &
  • [10] MASS-PRODUCTION OF ENGINEERS
    不详
    [J]. MECHANIK MIESIECZNIK NAUKOWO-TECHNICZNY, 1974, 47 (10): : 592 - 593