Association between interleukin 6, 10 gene polymorphisms and risk of type 2 diabetes mellitus in a Chinese population

Objective: To investigate the relationship between the interleukin 6 (IL6) gene single nucleotide polymorphisms (SNP)-572C/G (rs1800796), interleukin 10 (IL10)-592A/C(rs1800872) and risk of type 2 diabetes mellitus (T2DM) in a Chinese population. Materials and methods: We conducted a community-based, case-control study with a total of 568 subjects (284 patients and 284 controls) enrolled. Two polymorphisms of IL6 (rs1800796) and IL10 (rs1800872) were examined using TaqMan nuclease technology. Results: The study recruited 284 patients with T2DM and 284 healthy controls. Subjects carrying the-572 'G' allele had an increased risk of T2DM (odds ratio [OR] 1.46, 95% confidence interval [CI] 1.077, 1.862), as did those subjects carrying the-572 GG + CG genotype (OR 1.431, 95% CI 1.026, 1.997). For rs1800872, subjects carrying the -592 AA + AC genotype had a significantly increased risk of T2DM(OR 3.040, 95% CI 1.336, 6.917) too. In double combination, IL-6-572 GG and IL-10-592 AA increased the risk of T2DM up to 21.250 (3.280-137.667) times. Conclusions: Our results suggest that IL6 and IL10 genes increased the risk of T2DM. Individuals having a haplotype combination of GG and AA for IL-6 and IL-10 gene polymorphisms will have higher susceptibility and be at greater risk of developing T2DM. (C) 2016 Elsevier B.V. All rights reserved.