Specialization versus conservation: How Pol I and Pol III use the conserved architecture of the pre-initiation complex for specialized transcription

被引：8

作者：

Hoffmann, Niklas A. ^{[1
]}

Sadian, Yashar ^{[1
]}

Tafur, Lucas ^{[1
]}

Kosinski, Jan ^{[1
]}

Mueller, Christoph W. ^{[1
]}

机构：

[1] European Mol Biol Lab, Struct & Computat Biol Unit, Heidelberg, Germany

来源：

TRANSCRIPTION-AUSTIN | 2016年 / 7卷 / 04期

关键词：

pre-initiation complex; RNA polymerase I; RNA polymerase II; TFIIB; TFIIE; TFIIF; transcription;

D O I：

10.1080/21541264.2016.1203628

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Here, we discuss the overall architecture of the RNA polymerase I (Pol l) and III (Pol III) core enzymes and their associated general transcription factors in the context of models of the Pol I and Pol Ill pre-initiation complexes, thereby highlighting potential functional adaptations of the Pol I and Pol III enzymes to their respective transcription tasks. Several new insights demonstrate the great degree of specialization of each of the eukaryotic RNA polymerases that is only beginning to be revealed as the structural and functional characterization of all eukaryotic RNA polymerases and their pre-initiation complexes progresses.

引用

页码：127 / 132

页数：6

共 7 条

[1] Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex
Murakami, Kenji
Elmlund, Hans
Kalisman, Nir
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SCIENCE, 2013, 342 (6159) : 709 - +
[2] Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly
Gary Male
Alexander von Appen
Sebastian Glatt
Nicholas M. I. Taylor
Michele Cristovao
Helga Groetsch
Martin Beck
Christoph W. Müller
Nature Communications, 6
[3] Architecture of TFIIIC and its role in RNA polymerase III pre-initiation complex assembly
Male, Gary
von Appen, Alexander
Glatt, Sebastian
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Cristovao, Michele
Groetsch, Helga
Beck, Martin
Mueller, Christoph W.
NATURE COMMUNICATIONS, 2015, 6
[4] Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation
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Panova, Tatiana
Miller, Gail
Volkov, Arsen
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Russell, Jackie
Panov, Konstantin I.
Zomerdijk, Joost C. B. M.
NATURE COMMUNICATIONS, 2013, 4
[5] Topoisomerase IIα promotes activation of RNA polymerase I transcription by facilitating pre-initiation complex formation
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Tatiana Panova
Gail Miller
Arsen Volkov
Andrew C. G. Porter
Jackie Russell
Konstantin I. Panov
Joost C. B. M. Zomerdijk
Nature Communications, 4
[6] Architecture of the yeast Pol III pre-termination complex and pausing mechanism on poly(dT) termination signals
Girbig, Mathias
Xie, Juanjuan
Groetsch, Helga
Libri, Domenico
Porrua, Odil
Mueller, Christoph W.
CELL REPORTS, 2022, 40 (10):
[7] COMPETITION BETWEEN XENOPUS SATELLITE-I SEQUENCES AND POL-III GENES FOR STABLE TRANSCRIPTION COMPLEX-FORMATION
ANDREWS, DL
MILLSTEIN, L
HAMKALO, BA
GOTTESFELD, JM
NUCLEIC ACIDS RESEARCH, 1984, 12 (20) : 7753 - 7769

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