EFFECT OF EXTRACELLULAR MG2+ CONCENTRATION ON AGONIST-INDUCED CYTOSOLIC-FREE CA2+ TRANSIENTS

被引：16
|
作者：
ZHU, ZM [1 ]
TEPEL, M [1 ]
SPIEKER, C [1 ]
ZIDEK, W [1 ]
机构：
[1] UNIV MUNSTER, MED POLIKLIN, D-48129 MUNSTER, GERMANY
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH | 1995年 / 1265卷 / 01期
关键词：
MAGNESIUM; CYTOSOLIC FREE CA2+ CONCENTRATION; VASCULAR SMOOTH MUSCLE;
D O I：
10.1016/0167-4889(94)00231-3
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The modulating effects of extracellular Mg2+ concentration ([Mg2+](0)) on vascular contraction are well known. In the present study it was tested how the changes in cytosolic free Ca2+ concentration ([Ca2+](i),) induced by various agonists are modified by changes in [Mg2+](0). Extracellular Mg2+ deprivation increased the [Ca2+](i) response to arginine vasopressin, to angiotensin II and to thapsigargin, but not to 5-hydroxytryptamine and noradrenaline. Withdrawal of extracellular Ca2+ revealed that extracellular Mg2+ deprivation increased Ca2+ influx, but not Ca2+ release from cellular stores. The findings demonstrate that different responses of [Ca2+](i) to agonists may underlie the modulating effect of [Mg2+](0) on vascular contraction.
引用
收藏
页码：89 / 92
页数：4
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