PRIMARY FIBROMYALGIA IS RESPONSIVE TO S-ADENOSYL-L-METHIONINE

Forty-seven patients with primary fibromyalgia were treated with S-adenosyl-L-methionine (SAMe) 200 mg intramuscularly once daily, plus SAMe 400 mg orally twice daily, for 6 weeks. The treatment was preceded by a 7-day drug-free run-in washout period. SAMe significantly decreased tenderness of painful sites, significantly improved general well-being, and significantly reduced the mean scores (baseline vs day 42) for the Hamilton Rating Scale for Depression, the Zung Self-Rating Scale, the Hamilton Rating Scale for Anxiety, and Lorish and Maisiak's Face Scale. SAMe was well tolerated in all patients and no adverse side effects were reported.