PHARMACOKINETICS OF PUERARIN IN RATS, RABBITS, AND DOGS

被引：0
|
作者：
JIN, XL
ZHU, XY
机构：
来源：
ACTA PHARMACOLOGICA SINICA | 1992年 / 13卷 / 03期
关键词：
PUERARIN; PHARMACOKINETICS; SPECIES SPECIFICITY; HIGH PRESSURE LIQUID CHROMATOGRAPHY;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The puerarin was determined by HPLC with fluorescence detection. The plasma concentration-time course of puerarin in rats and dogs after iv was best fitted to a two-compartment open model, while that in rabbits was best fitted to a three-compartment open model. Species specificity was found among rats, rabbits, and dogs, calculated with compartment model program. The T1/2-beta after iv puerarin 9 mg . kg-1 in rats, rabbits, and dogs were 11, 21, and 67 min, respectively. There were no significant differences in pharmacokinetic parameters after iv 4.5-30 mg . kg-1 to rabbits and dogs.
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页码：284 / 288
页数：5
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