CHARACTERIZATION OF A YAC AND COSMID CONTIG CONTAINING MARKERS TIGHTLY LINKED TO THE MYOTONIC-DYSTROPHY LOCUS ON CHROMOSOME-19

被引：8

作者：

BUXTON, J

SHELBOURNE, P

DAVIES, J

JONES, C

PERRYMAN, MB

ASHIZAWA, T

BUTLER, R

BROOK, D

SHAW, D

DEJONG, P

MARKHAM, A

WILLIAMSON, R

JOHNSON, K

机构：

[1] BAYLOR COLL MED,TEXAS MED CTR,DEPT MED,HOUSTON,TX 77030

[2] BAYLOR COLL MED,TEXAS MED CTR,DEPT NEUROL,HOUSTON,TX 77030

[3] ICI PHARMACEUT PLC,DEPT BIOTECHNOL,MACCLESFIELD SK10 4TG,CHESHIRE,ENGLAND

[4] MIT,CTR CANC RES,CAMBRIDGE,MA 02139

[5] UNIV WALES COLL MED,INST MED GENET,CARDIFF CF4 4XN,S GLAM,WALES

[6] LAWRENCE LIVERMORE NATL LAB,CTR HUMAN GENOME,LIVERMORE,CA 94550

[7] ST MARYS HOSP,SCH MED,DEPT BIOCHEM & MOLEC GENET,LONDON W2 1PG,ENGLAND

来源：

GENOMICS | 1992年 / 13卷 / 03期

关键词：

D O I：

10.1016/0888-7543(92)90120-H

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Myotonic dystrophy (DM) is caused by a defect in an unknown gene that maps to 19q13.3, flanked by the tightly linked markers ERCC1 on the proximal side and D19S51 on the distal side. We report the isolation and characterization of overlapping YAC and cosmid clones around D19S51 for the construction of a physical map around this locus. The resulting contig contains the markers D19S51 and D19S62 (another new marker tightly linked to the DM locus) and the distal breakpoint of a radiation hybrid cell line used in the physical mapping of the DM region. We have compared the restriction maps of the YACs and cosmids with that of the genome to investigate the fidelity of these clones. © 1992.

引用

页码：526 / 531

页数：6

共 50 条

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