Excretion of Urinary IgG as a Diagnostic Factor in Overt Diabetic Nephropathy using Oral Hypoglycemic Drugs

Aim: To attempt to conclude the urinary IgG as the marker for early stages of diabetic nephropathy in patients with type II diabetes using oral hypoglycemic drug. Study design: 42 female patients and 27 male patients, age range 40-60 yrs with longstanding diabetes, were included in the study. Methods: The patients using oral hypoglycemic drug were taken from the In and Out patient department of Sir Ganga Ram Hospital. The electrophoretic patterns of 24 hr urinary proteins in diabetic patients were studied on 10% SDS gradient polyacrylamide gel electrophoresis. 24 hr urinary protein of patients was estimated. Results: Electrophoretic profile showed a condition of proteinurea (both high molecular weight and low molecular weight). A significantly increased raw volume (concentration) and density of IgG was observed in urine of patient. Conclusion: Urinary IgG excretion is an important prognostic factor in idiopathic membranous nephropathy. It is therefore recommended that early recognition of level of IgG is indicative of the renal changes that may increase the chance of preventing the development of diabetic nephropathy.