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Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Key Lab Rheumatol & Clin Immunol, Minist Educ,Peking Union Med Coll Hosp, Beijing 100730, Peoples R China Chinese Acad Med Sci, Dept Rheumatol & Clin Immunol, Key Lab Rheumatol & Clin Immunol, Minist Educ,Peking Union Med Coll Hosp, Beijing 100730, Peoples R China