EFFECT OF DAU-6215, A NOVEL 5-HT3 RECEPTOR ANTAGONIST, ON SCOPOLAMINE-INDUCED AMNESIA IN THE RAT IN A SPATIAL-LEARNING TASK

The effects of different doses (1, 10, 30, and 100 mu g/kg, IP) of a new 5-hydroxytryptamine(3) (5-HT3) receptor antagonist, 3-alpha-tropanyl)1H-benzimidazolone-3-carboxamide chloride (DAU 6215), on memory and performance deficits induced by SC 0.2 mg/kg scopolamine were assessed in the Morris water maze task. No effect was observed on the performance of rats treated with DAU 6215 alone. The doses of 10 and 30 mu g/kg DAU 6215 attenuated these scopolamine-induced behavioral deficits.