Dynamic ERK signaling regulation in intestinal tumorigenesis

被引：1
|
作者：
Muta, Yu [1 ,2 ]
Matsuda, Michiyuki [1 ,3 ]
Imajo, Masamichi [3 ]
机构：
[1] Kyoto Univ, Grad Sch Med, Dept Pathol & Biol Dis, Kyoto, Japan
[2] Kyoto Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Kyoto, Japan
[3] Kyoto Univ, Grad Sch Biostudies, Lab Bioimaging & Cell Signaling, Kyoto 6068501, Japan
来源：
MOLECULAR & CELLULAR ONCOLOGY | 2018年 / 5卷 / 05期
基金：
日本学术振兴会;
关键词：
ERK MAP kinase; EGFR; ErbB2; the intestinal epithelium; tumorigenesis; in vivo imaging;
D O I：
10.1080/23723556.2018.1506684
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Extracellular signal-regulated kinase (ERK) plays a critical role in tissue homeostasis and tumorigenesis. By utilizing live imaging approaches, we recently uncovered ERK activity dynamics in the intestinal epithelium. Notably, we showed that ERK activity dynamics are defined by composite regulation from two distinct upstream receptors, and alteration of their functional balance underlies tumor cell-specific traits. Here, we discuss these findings.
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页数：3
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