A VERSATILE ENTRY INTO THE SYNTHESIS OF ALPHA-(MONOFLUOROMETHYL) AMINO-ACIDS - PREPARATION OF ALPHA-(MONOFLUOROMETHYL) SERINE AND (E)-DEHYDRO-ALPHA-(MONOFLUOROMETHYL) ORNITHINE

被引：8
|
作者：
VANHIJFTE, L
HEYDT, V
KOLB, M
机构：
[1] Marion Merrell Dow Research Institute Strasbourg Research Center, 67009 Strasbourg Cedex
来源：
TETRAHEDRON LETTERS | 1993年 / 34卷 / 30期
关键词：
D O I：
10.1016/S0040-4039(00)74090-1
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new entry to the synthesis of alpha-(monofluoromethyl) amino acids is described. The synthesis is based on a Strecker reaction on an alpha-(monofluoromethyl) ketone. As an example, alpha-(monofluoromethyl) serine was synthesized and used as starting material for a new synthesis of (E)-dehydro-alpha-(monofluromethyl ornithine.
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页码：4793 / 4796
页数：4
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