CONTROLLED-RELEASE SYSTEMS OF BIODEGRADABLE POLYMERS .1. HYDROLYTIC DEGRADATION OF BIODEGRADABLE ALIPHATIC POLYESTERS

被引：0
|
作者：
RAFLER, G [1 ]
JOBMANN, M [1 ]
机构：
[1] FRAUNHOFER INST APPL POLYMER RES,TELTOW,GERMANY
来源：
PHARMAZEUTISCHE INDUSTRIE | 1994年 / 56卷 / 06期
关键词：
CONTROLLED RELEASE SYSTEMS; POLYESTERS; ALIPHATIC; DEGRADATION; POLYMERS; BIODEGRADABLE;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The degradation of aliphatic polyesters were investigated in dependence on the chemical polymer structure and the matrix form. The macroscopic rate of polyester degradation is determined by the chemical kinetics of ester hydrolysis and the rate of mass transport processes in the polymeric matrix. Important chemical factors of the biodegradation are the ratio of cleavable ester bonds to stable bonds as well as the accessibility, of cleavable bonds by water.
引用
收藏
页码：565 / 570
页数：6
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