POTENTIAL ANTIMALARIALS .10. DI-MANNICH BASES OF 4-(7'-TRIFLUOROMETHYL-1',5'-NAPHTHYRIDIN-4'-YLAMINO)PHENOL AND N-(4'-DIETHYLAMINO-1'-METHYLBUTYL)-7-TRIFLUOROMETHYL-1,5-NAPHTHYRIDIN-4-AMINE

The syntheses of some di-Mannich bases derived from 4-(7′-trifluoromethyl-l′)5′-naphthyridin-4′- ylamino) phenol and of N-(4′-diethylamino-l′-methylbutyl)-7-trifluoromethyl-l, 5-naphthyridin- 4-amine from 3-chloro-5-trifluoromethylpyridine via 4-chloro-7-trifluoromethyl-l, 5-naphthyrid- ine are described. In tests in vitro against the fcq-27 strain of Plasmodium falciparum these compounds were slightly less active than their 7-bromo analogues. © 1990 ASEG.