The geodynamic environment in the Late Paleozoic continental margin of the Paleo-Tethys and related magmatic and metallogenic zonations are described in an example of the western part of the middle Tien'-Shan' (the Chatkal region). During the Middle Devonian-Early Carboniferous, a geodynamic environment was compatible with conditions of a passive continental margin, which gave way to nonmagmatic subduction in the Early Carboniferous. During the late Paleozoic, subduction of the oceanic crust under the northern active continental margin was accompanied by the development of an epicontinental volcano-plutonic belt. Magmatic rocks reveal the following lateral and age zonation from southeast to northwest: calc-alkaline rocks --> latites --> agpaites --> plumasites, alkaline granites and rhyolytes --> alkaline (potassium) gabbroids and basaltic rocks. Metallogenic zones of base (Cu, Pb, and Zn), noble (Au, Ag), and rare (Hg, As, Sb, Mo, W, and Sn) metals were correlated with zones of magmatic rocks within the belt from its frontal part to the backside.