INJECTION OF ANTINEUROPEPTIDE-Y GAMMA-GLOBULIN INTO THE HYPOTHALAMIC PARAVENTRICULAR NUCLEUS DECREASES FOOD-INTAKE IN RATS

被引：72
|
作者：
SHIBASAKI, T [1 ]
ODA, T [1 ]
IMAKI, T [1 ]
LING, N [1 ]
DEMURA, H [1 ]
机构：
[1] WHITTIER INST,DEPT MOLEC ENDOCRINOL,LA JOLLA,CA 92037
来源：
BRAIN RESEARCH | 1993年 / 601卷 / 1-2期
关键词：
NEUROPEPTIDE-Y; FEEDING BEHAVIOR; PARAVENTRICULAR NUCLEUS; ANTI-NPY GAMMA-GLOBULIN; IMMUNONEUTRALIZATION; ARCUATE NUCLEUS;
D O I：
10.1016/0006-8993(93)91727-A
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibited food intake for 1 h after the injection compared with rats that received normal rabbit gamma-globulin. This result suggests that NPY in the paraventricular nucleus plays a role in stimulating feeding behavior.
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收藏
页码：313 / 316
页数：4
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共 19 条
  • [1] LATERAL HYPOTHALAMIC INJECTION OF BOMBESIN DECREASES FOOD-INTAKE IN RATS
    STUCKEY, JA
    GIBBS, J
    [J]. BRAIN RESEARCH BULLETIN, 1982, 8 (06) : 617 - 621
  • [2] GASTRIC-MOTILITY AND FOOD-INTAKE IN RATS AFTER LESIONS OF HYPOTHALAMIC PARAVENTRICULAR NUCLEUS
    FLANAGAN, LM
    DOHANICS, J
    VERBALIS, JG
    STRICKER, EM
    [J]. AMERICAN JOURNAL OF PHYSIOLOGY, 1992, 263 (01): : R39 - R44
  • [3] DIURNAL RHYTHMS OF PARAVENTRICULAR HYPOTHALAMIC NOREPINEPHRINE AND FOOD-INTAKE IN RATS
    MORIEN, A
    WELLMAN, PJ
    FOJT, J
    [J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1995, 52 (01) : 169 - 174
  • [4] DEFICITS IN THE CONTROL OF FOOD-INTAKE AFTER HYPOTHALAMIC PARAVENTRICULAR NUCLEUS LESIONS
    SHORPOSNER, G
    AZAR, AP
    INSINGA, S
    LEIBOWITZ, SF
    [J]. PHYSIOLOGY & BEHAVIOR, 1985, 35 (06) : 883 - 890
  • [5] THE ROLE OF THE DORSOMEDIAL HYPOTHALAMIC NUCLEUS IN THE CONTROL OF FOOD-INTAKE IN RATS
    RIETVELD, WJ
    HEKKENS, WTJM
    AARDOOM, OR
    [J]. EXPERIENTIA, 1984, 40 (11): : 1304 - 1304
  • [6] EFFECTS OF NEUROPEPTIDE-Y (NPY) MICROINJECTIONS INTO THE PARAVENTRICULAR NUCLEUS ON FOOD-INTAKE IN ADULT AND OLD RATS
    PICH, EM
    GAVIOLI, G
    MESSORI, B
    ZINI, I
    ZOLI, M
    AGNATI, LF
    [J]. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1987, 410 (4-5): : S24 - S24
  • [7] NEUROPEPTIDE Y STIMULATION OF PARAVENTRICULAR NUCLEUS OF THE HYPOTHALAMUS - EVIDENCE FOR A CENTER COORDINATING THERMOGENESIS AND FOOD-INTAKE
    BILLINGTON, CJ
    BRIGGS, JE
    GRACE, M
    LEVINE, AS
    [J]. CLINICAL RESEARCH, 1991, 39 (02): : A355 - A355
  • [8] PRL-releasing peptide inhibit food intake in male rats via the dorsomedial hypothalamic nucleus and not the paraventricular hypothalamic nucleus
    Seal, LJ
    Small, CJ
    Dhillo, WS
    Stanley, SA
    Abbott, CR
    Ghatei, MA
    Bloom, SR
    [J]. ENDOCRINOLOGY, 2001, 142 (10) : 4236 - 4243
  • [9] Paraventricular Hypothalamic Nucleus (PVN) Glucosensitive Neurons Stimulate Food Intake in 18 Hours Food Deprived Male Rats
    Brojeni, Masoud Shareghi
    Nasseri, Fatemeh
    Haghparast, Abbas
    Eliassi, Afsaneh
    [J]. NEUROENDOCRINOLOGY, 2021, 111 (SUPPL 1) : 22 - 22
  • [10] EFFECTS OF PARAVENTRICULAR NUCLEUS INJECTIONS OF CCK-8 AND CCK RECEPTOR ANTAGONIST DEVAZEPIDE ON FOOD-INTAKE IN RATS
    BLEVINS, JE
    STANLEY, BG
    REIDELBERGER, RD
    [J]. APPETITE, 1994, 23 (03) : 295 - 295
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