Tumor Microenvironment in Head and Neck Squamous Cell Carcinomas

被引：6
|
作者：
Eskiizmir, Gorkem [1 ]
机构：
[1] Celal Bayar Univ, Tip Fak, Kulak Burun Bogaz & Bas Boyun Cerrahisi Anabilim, Manisa, Turkey
来源：
TURKISH ARCHIVES OF OTORHINOLARYNGOLOGY | 2015年 / 53卷 / 03期
关键词：
Carcinoma; squamous cell of head and neck; head and neck neoplasms; tumor microenvironment;
D O I：
10.5152/tao.2015.1065
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Recent studies about solid tumors demonstrated that tumor microenvironment has an important role in tumor progression, aggressivity, and metastasis process, in addition to genetic aberrations and molecular alterations of cancer cells. Therefore, the crosstalks between cancerous and noncancerous cells and metabolic changes in tumor microenvironment cause significant detrimental effects. The purpose of this review is to present the role and effect of noncancerous cells and their crosstalks with cancer cells, metabolic changes in tumor microenvironment, and to discuss the clinical significance of all these factors with respect to the current literature.
引用
收藏
页码：120 / 127
页数：8
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