ACTINOMYCIN-D DECREASES PROTEIN-KINASE-C CONTENT AND INDUCES NEURITOGENESIS IN NEUROBLASTOMA-CELLS

被引：6

作者：

MINANA, MD ^{[1
]}

FELIPO, V ^{[1
]}

GRISOLIA, S ^{[1
]}

机构：

[1] CSIC,CTR ASOCIADO,INST INVEST CITOL CAJA AHORROS VALENCIA,AMADEO SABOYA 4,E-46010 VALENCIA,SPAIN

来源：

FEBS LETTERS | 1991年 / 280卷 / 02期

关键词：

NEURITOGENESIS; PROTEIN KINASE-C; ACTINOMYCIN-D; NEUROBLASTOMA;

D O I：

10.1016/0014-5793(91)80302-J

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously reported that inhibition of protein kinase C induces differentiation of neuroblastoma cells in culture. It is shown now that actinomycin D, a well known inhibitor of DNA synthesis, reduces selectively the content of protein kinase C and induces neuritogenesis in Neuro 2a cells in culture.

引用

页码：245 / 246

页数：2

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