ANTIMYCOBACTERIAL ACTIVITY OF 4-AND 3,4-SUBSTITUTED COUMARINS

被引：0
|
作者：
Angelova, V. T. [1 ]
Valcheva, V. [2 ]
Stavrakov, G. [1 ]
机构：
[1] Med Univ Sofia, Fac Pharm, BU-1000 Sofia, Bulgaria
[2] Bulgarian Acad Sci, Inst Microbiol, BU-1113 Sofia, Bulgaria
来源：
PHARMACIA | 2014年 / 61卷 / 04期
关键词：
aminocoumarins; aminoalcohols; amidoamines; tuberculosis;
D O I：
暂无
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The present article describes the evaluation of the in vitro activity against M. tuberculosis H37Rv of eight coumarin-derived aminoalcohols and amidoamines. Seven of the compounds display activity between 10 and 20 times higher than the classicall anti-TB drug ethambutol. The combination of coumarin scaffold with aminoalcohol fragments gave the most promising activities with MICs up to 0.32 mu M.
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页码：3 / 6
页数：4
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