EFFECT OF LYSOPHOSPHATIDIC ACID ON THE PREIMPLANTATION DEVELOPMENT OF MOUSE EMBRYOS

被引：56

作者：

KOBAYASHI, T ^{[1
]}

YAMANO, S ^{[1
]}

MURAYAMA, S ^{[1
]}

ISHIKAWA, H ^{[1
]}

TOKUMURA, A ^{[1
]}

AONO, T ^{[1
]}

机构：

[1] UNIV TOKUSHIMA, FAC PHARMACEUT SCI, TOKUSHIMA 770, JAPAN

来源：

FEBS LETTERS | 1994年 / 351卷 / 01期

关键词：

EMBRYO; LYSOPHOSPHATIDIC ACID; PERTUSSIS TOXIN; MOUSE;

D O I：

10.1016/0014-5793(94)00815-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effect of lysophosphatidic acid (LPA) on the preimplantation development of mouse embryos was examined. The blastocyst rates from 2-cell and 4-cell stage embryos were significantly higher in the presence of LPA at the pronuclear stage. However, the blastocyst rate from 4-cell stage embryos was significantly lower when LPA was added to the medium at the 4-cell stage than when it was added at the pronuclear stage. Furthermore, pretreatment of pronuclear stage embryos with pertussis toxin suppressed LPA-induced embryo development, suggesting that it is probably mediated by a Gi-protein-linked receptor.

引用

页码：38 / 40

页数：3

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