INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR FUNCTION IN NEONATAL CARDIOMYOCYTES

被引：5
|
作者：
FITZGERALD, M [1 ]
ANDERSON, KE [1 ]
WOODCOCK, EA [1 ]
机构：
[1] BAKER MED RES INST,CELL BIOCHEM LAB,PRAHRAN,VIC 3141,AUSTRALIA
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY-MOLECULAR PHARMACOLOGY SECTION | 1994年 / 268卷 / 02期
关键词：
INOSITOL 1,4,5-TRISPHOSPHATE; INOSITOL 1,4,5-TRISPHOSPHATE RECEPTOR; HEART; RAT; CA2+ RELEASE; NEONATAL CARDIOMYOCYTE;
D O I：
10.1016/0922-4106(94)90200-3
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We have previously reported that the metabolism of inositol(1,4,5)tris phosphate (Ins(1,4,5)P-3)is altered when rat neonatal ventricular cardiomyocytes are isolated and cultured. In the current study we show that the mass content of Ins(1,4,5)P-3 is lower in the isolated cells than in the intact tissue. However, the properties of the Ins(1,4,5)P-3 receptors were not different in the two preparations and the isolated cells remained insensitive to Ins(1,4,5)P-3 in terms of Ca-45(2+) release. Thus, despite the altered pattern of metabolism of Ins(1,4,5)P-3 in isolated neonatal cells, the properties of the receptors were similar to those reported in other myocardial preparations.
引用
收藏
页码：275 / 278
页数：4
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