Prenatal Exposure to Misoprostol and Associated Congenital Malformations

Misoprostol is a prostaglandin E1 analogue with abortive properties and limited efficacy, with multiple descriptions of association to congenital defects in newborn infants exposed in utero. We introduce five cases of newborn with congenital defects collected through project ECLAMC-Colombia and one case assessed by consultation to genetics service at Hospital Universitario San Ignacio with antecedent of exposition in utero to misoprostol. The more frequent defects associated to exposition to misoprostol are clubfoot, cranial nerve affection, terminal transverse limb defects. The teratogenic effects of this drug haven't been clarified, meanwhile all related cases must be reported in order to increase evidence related to its teratogenicity.