SEPARATION OF DRUGS BY PACKED-COLUMN SUPERCRITICAL-FLUID CHROMATOGRAPHY .2. ANTIDEPRESSANTS

被引：34
|
作者：
BERGER, TA
WILSON, WH
机构：
[1] Hewlett Packard Company, Wilmington, Delaware, 19808
来源：
JOURNAL OF PHARMACEUTICAL SCIENCES | 1994年 / 83卷 / 03期
关键词：
D O I：
10.1002/jps.2600830305
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Antidepressants can be rapidly and efficiently separated by packed-column supercritical fluid chromatography with a tertiary mobile phase. Ten antidepressants were nearly baseline resolved in <6 min without programming. Calculated detection limits with a 5-mu L injection volume were as low as 88 ppb. The effects of temperature, pressure, and modifier concentration on retention and selectivity were studied. Changing modifier concentration caused significant changes in selectivity. Several relationships between solute structure and selectivity changes were noted.
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页码：287 / 290
页数：4
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