A CONVENIENT PROCEDURE FOR THE FORMYLATION OF AMINES AND ALCOHOLS USING CYANOMETHYL FORMATE

被引：29
|
作者：
DEUTSCH, J [1 ]
NICLAS, HJ [1 ]
机构：
[1] CTR SELECT ORGAN SYNTH BERLIN ADLERSHOF,RUDOWER CHAUSSEE 5,O-1199 BERLIN,GERMANY
来源：
SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 11期
关键词：
D O I：
10.1080/00397919308011251
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A simple method for the direct formylation of amines using cyanomethyl formate is described. The formylation succeeds in moderate to high yields under mild and neutral conditions. Thus, formamides 2a-f, 2i-m are obtained at room temperature. A chemoselective N-formylation is achieved in the case of ethanolamine. The formylation of nitroanilines and the O-formylation of alcohols only succeeds in the presence of a catalytic amount of imidazole leading to 2g,h and 3a-e, respectively.
引用
收藏
页码：1561 / 1568
页数：8
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