PERCUTANEOUS-ABSORPTION OF ZINC FROM ZINC-OXIDE APPLIED TOPICALLY TO INTACT SKIN IN MAN

被引：50
|
作者：
AGREN, MS
机构：
[1] Department of Pathology, Faculty of Health Sciences
来源：
DERMATOLOGICA | 1990年 / 180卷 / 01期
关键词：
human skin; suction blisters; Zinc penetration;
D O I：
10.1159/000247982
中图分类号：
R75 [皮肤病学与性病学];
学科分类号：
100206 ;
摘要：
The penetration of zinc through normal skin treated with a zinc oxide (25%) medicated occlusive dressing was studied. The mean release rate of zinc to the skin was 5 μg/cm2/h. After 48 h of treatment suction blisters were raised by the 'Kiistala' method. The zinc concentration of the epidermis, blister fluid and dermis was increased beneath the zinc dressing compared to control-treated skin. The study shows that zinc permeates intact human skin from topically applied zinc oxide in vivo.
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页码：36 / 39
页数：4
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