LIPOSOMES WITH CLINDAMYCIN HYDROCHLORIDE IN THE THERAPY OF ACNE-VULGARIS

Liposomes with clindamycin hydrochloride were prepared using either soya lecithin and cholesterol or hostaphate and cholesterol. In vitro dissolution studies showed sustained release of the drug from hostaphate liposomes compared to lecithin liposomes. Clinical treatment of Acne vulgaris with a lotion of liposomal drug shows better efficacy than non-liposome lotion forms (especially of the treatment of pustules where clinical improvement was 77% of initial number). Application of a conventional lotion solution, a non-liposomal emulsion lotion and a liposomal emulsion lotion resulted in decreases of 42.9, 48.3 and 62.8%, respectively, in the total number of lesions after a 4 week treatment. The result support the possibility of developing products utilizing the liposomal dosage form that are superior to existing dosage forms for topical therapy.