HEPATOCYTE INCLUSIONS OF ALPHA-1-ANTICHYMOTRYPSIN IN A PATIENT WITH PARTIAL DEFICIENCY OF ALPHA-1-ANTICHYMOTRYPSIN AND CHRONIC LIVER-DISEASE

被引：16

作者：

LINDMARK, B

MILLWARDSADLER, H

CALLEA, F

ERIKSSON, S

机构：

[1] SOUTHAMPTON GEN HOSP,DEPT PATHOL,SOUTHAMPTON SO9 4XY,HANTS,ENGLAND

[2] IST GIANNINA GASLINI,I-16148 GENOA,ITALY

来源：

HISTOPATHOLOGY | 1990年 / 16卷 / 03期

关键词：

chronic active hepatitis; endoplasmic reticulum; fibrinogen; liver; δ [!sub]1[!/sub]‐antichymotrypsin; δ [!sub]1[!/sub]‐antitrypsin;

D O I：

10.1111/j.1365-2559.1990.tb01107.x

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

We present a case of chronic liver disease with selective and exclusive hepatocyte endoplasmic reticulum storage of δ1‐antichymotrypsin in the form of granules, detected by specific immunohistochemistry at the light microscopy level and corresponding to material found in dilated endoplasmic reticulum of hepatocytes by electron microscopy. The patient had intermediate deficiency of δ1‐antichymotrypsin. Thus, the hepatocyte accumulation of δ1‐antichymotrypsin may indicate the presence of an export block resembling that of a closely‐related protein, namely PiZ δ1‐antitrypsin. It is proposed that hepatocyte storage of δ1‐antichymotrypsin may be an expression of an inborn error of metabolism bearing the characteristics of endoplasmic reticulum storage diseases such as PiZ δ1‐antitrypsin deficiency and hereditary hypofibrinogenaemia. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：221 / 225

页数：5

共 50 条

[1] PARTIAL DEFICIENCY OF ALPHA-1-ANTICHYMOTRYPSIN IS ASSOCIATED WITH CHRONIC CRYPTOGENIC LIVER-DISEASE
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[2] PLASMA ALPHA-1-ANTICHYMOTRYPSIN IN LIVER-DISEASE
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[J]. CLINICA CHIMICA ACTA, 1985, 152 (03) : 261 - 269
[3] A CASE OF PARTIAL DEFICIENCY OF ALPHA-1-ANTICHYMOTRYPSIN
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[J]. CLINICAL CHEMISTRY, 1985, 31 (10) : 1739 - 1740
[4] ALPHA-1-ANTICHYMOTRYPSIN
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[J]. JOURNAL OF MEDICINE, 1985, 16 (1-3) : 101 - 128
[5] FAMILIAL ALPHA-1-ANTICHYMOTRYPSIN DEFICIENCY
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[J]. ACTA MEDICA SCANDINAVICA, 1986, 220 (05): : 447 - 453
[6] HUMAN ALPHA-1-ANTICHYMOTRYPSIN
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[J]. METHODS IN ENZYMOLOGY, 1981, 80 : 765 - 771
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RONCO, C
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[J]. NEPHRON, 1990, 56 (04): : 387 - 390
[9] SPUTUM STUDIES OF ALPHA-1-ANTICHYMOTRYPSIN
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[10] INTERACTION OF HUMAN ALPHA-1-ANTICHYMOTRYPSIN WITH CHYMOTRYPSIN
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