EFFECT OF BISMUTH SUBSALICYLATE ON CIPROFLOXACIN BIOAVAILABILITY

被引：10
|
作者：
RAMBOUT, L
SAHAI, J
GALLICANO, K
OLIVERAS, L
GARBER, G
机构：
[1] OTTAWA GEN HOSP,CLIN INVEST UNIT,OTTAWA K1H 8L6,ON,CANADA
[2] OTTAWA GEN HOSP,DEPT MED,DIV INFECT DIS,OTTAWA,ON,CANADA
[3] OTTAWA GEN HOSP,DEPT BIOCHEM,OTTAWA,ON,CANADA
[4] HLTH & WELF CANADA,BUR DRUG RES,OTTAWA K1A 0L2,ON,CANADA
来源：
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 1994年 / 38卷 / 09期
关键词：
D O I：
10.1128/AAC.38.9.2187
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
A single oral dose of 528 mg of bismuth subsalicylate (30 ml of Pepto-Bismol) had no significant effect ori the plasma pharmacokinetics of a single oral dose of 750 mg of ciprofloxacin administered to 12 healthy volunteers (six men and six women). These results suggest that ciprofloxacin bioavailability will not be significantly decreased by single doses of bismuth subsalicylate when the two medications are administered simultaneously.
引用
收藏
页码：2187 / 2190
页数：4
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