EVOLUTION OF ANDROGEN DEPRIVATION THERAPY

被引：0

作者：

Raj, Ganesh V. ^{[1
]}

Selth, Luke A. ^{[2
,3
]}

Day, Tanya K. ^{[2
,3
]}

Tilley, Wayne D. ^{[2
,3
]}

机构：

[1] Univ Texas SW Med Ctr Dallas, Dept Urol, Dallas, TX 75390 USA

[2] Univ Adelaide, Dame Roma Mitchell Canc Res Labs, Discipline Med, Adelaide, SA 5005, Australia

[3] Univ Adelaide, Sch Med, Freemasons Fdn Ctr Mens Hlth, Adelaide, SA 5005, Australia

来源：

CANCER FORUM | 2015年 / 39卷 / 03期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The androgen signalling axis is critical for the development and progression of prostate cancer. Therefore, the mainstay treatments for metastatic disease are hormonal manipulations aimed at reducing androgen levels and/or blocking the androgen receptor, collectively termed androgen deprivation therapy. This review will discuss the evolution of androgen deprivation therapy since it was instigated more than 70 years ago, and outline the key mechanisms underlying its inevitable failure. We will also briefly introduce potential new androgen signalling-targeted therapies in clinical development.

引用

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页码：189 / 194

页数：6

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