SPONTANEOUS CYCLIZATION OF THE ASPARTIC-ACID SIDE-CHAIN TO THE SUCCINIMIDE DERIVATIVE

被引：26
|
作者：
CAPASSO, S [1 ]
MAZZARELLA, L [1 ]
SICA, F [1 ]
ZAGARI, A [1 ]
SALVADORI, S [1 ]
机构：
[1] UNIV FERRARA,DEPT PHARMACEUT SCI,I-44100 FERRARA,ITALY
来源：
JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1992年 / 12期
关键词：
D O I：
10.1039/c39920000919
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
At equilibrium in acidic solution the succinimide derivative, formed by cyclization reaction of the Asp side chain, predominates; at a pH close to the apparent pK(a) of the Asp residue this reaction is relatively fast with a t1/2 of a few days.
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页码：919 / 921
页数：3
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