CARBOPLATIN-RADIATION INTERACTION IN SQUAMOUS-CELL CARCINOMA CELL-LINES

被引：0
|
作者：
PEKKOLAHEINO, K
KULMALA, J
GRENMAN, R
机构：
[1] UNIV TURKU,DEPT OTOLARYNGOL,SF-20520 TURKU 52,FINLAND
[2] UNIV TURKU,DEPT RADIOTHERAPY & ONCOL,SF-20520 TURKU 52,FINLAND
[3] UNIV TURKU,DEPT MED BIOCHEM,SF-20520 TURKU 52,FINLAND
来源：
ARCHIVES OF OTOLARYNGOLOGY-HEAD & NECK SURGERY | 1992年 / 118卷 / 12期
关键词：
D O I：
暂无
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Chemoradiotherapy has been considered one of the most promising improvements in the treatment of advanced head and neck cancer. This article describes in vitro chemosensitivity to carboplatin in five squamous cell carcinoma cell lines established from head and neck cancers and in one vulvar squamous cell carcinoma cell line. Sensitivity to carboplatin was found to vary markedly when using the 96-well plate clonogenic assay and continuous drug exposure. The difference in carboplatin response between the most sensitive and the most resistant cell lines was fourfold. No cross-resistance was observed between inherent radiosensitivity and chemosensitivity. Effects of concomitant use of carboplatin and radiation were further investigated in the two cell lines that were found to be most sensitive to carboplatin. The drug was administered 1 hour before acute radiation doses, and an additive effect was observed in both cell lines.
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页码：1312 / 1315
页数：4
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