AGONIST-SPECIFIC COUPLING OF A CLONED DROSOPHILA OCTOPAMINE TYRAMINE RECEPTOR TO MULTIPLE 2ND MESSENGER SYSTEMS

被引：212
|
作者：
ROBB, S
CHEEK, TR
HANNAN, FL
HALL, LM
MIDGLEY, JM
EVANS, PD
机构：
[1] UNIV CAMBRIDGE,DEPT ZOOL,AFRC,MOLEC SIGNALLING LAB,CAMBRIDGE CB2 3EJ,ENGLAND
[2] SUNY BUFFALO,SCH PHARM,DEPT BIOCHEM PHARMACOL,BUFFALO,NY 14260
[3] UNIV STRATHCLYDE,DEPT PHARMACEUT SCI,GLASGOW G1 1XW,SCOTLAND
来源：
EMBO JOURNAL | 1994年 / 13卷 / 06期
关键词：
DROSOPHILA; G-PROTEIN-COUPLED RECEPTORS; OCTOPAMINE; 2ND MESSENGERS; TYRAMINE;
D O I：
10.1002/j.1460-2075.1994.tb06385.x
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy.
引用
收藏
页码：1325 / 1330
页数：6
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