SYNTHESES OF A REGIOISOMER OF N-[4-[2-(2-AMINO-4(3H)-OXO-7H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)ETHYL]BENZOYL)-L-GLUTAMIC ACID (LY231514), AN ACTIVE THYMIDYLATE SYNTHASE INHIBITOR AND ANTITUMOR AGENT

被引：0

作者：

TAYLOR, EC

YOUNG, WB

CHAUDHARI, R

PATEL, HH

机构：

来源：

HETEROCYCLES | 1993年 / 36卷 / 08期

关键词：

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Two independent routes to N-(4-12-(2-amino-4(3H)-oxo-7H-pyrrolo[2,3-d]pyrimidin-6-yl)ethyl]benzoyl}-L-glutamic acid, a regioisomer of the potent TS inhibitor and antitumor agent LY231514. are described. Preliminary in vitro cell culture evaluation has shown that attachment of the ethanobenzoyl-glutamate moiety of LY231514 to position 6 of the pyrrolo-pyrimidine ring system rather than to position 5 results in complete loss of biological activity.

引用

页码：1897 / 1908

页数：12

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