DISPOSITION OF CLEBOPRIDE AFTER INTRAVENOUS ADMINISTRATION

被引：1
|
作者：
LENZ, HJ
HICKING, W
ROBINSON, PR
EHNINGER, G
机构：
[1] Medizinische Universitätsklinik Abteilung II, Tübingen, D-7400, Otfried-Müller-Strasse
[2] Kali-Chemie AG, Hannover
[3] Simbec Research Ltd, Merthyr Tydfil, Mid Glamorgan
来源：
DRUG INVESTIGATION | 1992年 / 4卷 / 01期
关键词：
D O I：
10.1007/BF03258378
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
A pharmacokinetic study of clebopride, a new benzamide, was carried out within a phase I study. Plasma concentrations were measured using capillary gas chromatography with negative ion chemical ionisation mass spectrometry. The pharmacokinetic parameters are adequately described by a 2-compartment model with a terminal half-life of 9.5 +/- 3.9 (SD) hours and a volume of distribution in steady-state of 3.9 L/kg. The mean clearance was 5.2 ml/min/kg. The terminal half-life of the main active metabolite, N-desbenzyl-clebopride, is 1.5 +/- 1.0 (SD) hours. These results suggest that clebopride can be used as a single dose for chemotherapy-induced nausea and vomiting, due to its long half-life.
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收藏
页码：47 / 50
页数：4
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