NO GENETIC-LINKAGE DETECTED FOR SCHIZOPHRENIA TO XQ27-Q28

被引：15
|
作者：
DELISI, LE
CROW, TJ
DAVIES, KE
TERWILLIGER, JD
OTT, J
RAM, R
FLINT, T
BOCCIO, A
机构：
[1] NORTHWICK PK HOSP & CLIN RES CTR,CLIN RES CTR,DIV PSYCHIAT,HARROW HA1 3UJ,MIDDX,ENGLAND
[2] UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOLEC MED,OXFORD OX3 9DU,ENGLAND
[3] COLUMBIA UNIV,DEPT PSYCHIAT,NEW YORK,NY 10027
[4] COLUMBIA UNIV,DEPT GENET & DEV,NEW YORK,NY 10027
来源：
BRITISH JOURNAL OF PSYCHIATRY | 1991年 / 158卷
关键词：
D O I：
10.1192/bjp.158.5.630
中图分类号：
R749 [精神病学];
学科分类号：
100205 ;
摘要：
The hypothesis that at least a subgroup of familial cases of schizophrenia could be due to a genetic defect on the X chromosome is supported by the observation of an excess of X-chromosome aneuploidies (XXX and XXY) among populations of patients with psychosis. The distal long arm, Xq27-q28, is a candidate region where linkage has been claimed to manic-depressive disorder and a fragile site has been associated with schizophrenia spectrum disorders. The present study excluded linkage to a large part of this region using four polymorphic probes and multipoint lod-score analysis in 10 families with multiple members with schizophrenia.
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收藏
页码：630 / 634
页数：5
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