CORRECTION OF NEUTROPHIL CHEMOTAXIS DEFECT IN PATIENTS WITH GAUCHER DISEASE BY LOW-DOSE ENZYME REPLACEMENT THERAPY

被引：26
|
作者：
ZIMRAN, A
ABRAHAMOV, A
AKER, M
MATZNER, Y
机构：
[1] HADASSAH UNIV HOSP, HEMATOL UNIT, JERUSALEM, ISRAEL
[2] HADASSAH UNIV HOSP, SHAARE ZEDEK MED CTR, GAUCHER CLIN, JERUSALEM, ISRAEL
[3] HADASSAH UNIV HOSP, DEPT PEDIAT, JERUSALEM, ISRAEL
来源：
AMERICAN JOURNAL OF HEMATOLOGY | 1993年 / 43卷 / 01期
关键词：
CEREDASE; INFECTION; GLUCOCEREBROSIDASE;
D O I：
10.1002/ajh.2830430118
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We have recently described a chemotactic defect in severely afflicted Gaucher disease patients. Two of the patients were treated with low-dose intravenous enzyme replacement (Ceredase). Marked improvement in their hematological status, organomegaly, and growth was observed. In addition, their chemotactic defect and their tendency towards infections were corrected within 1 year of treatment.
引用
收藏
页码：69 / 71
页数：3
相关论文
共 50 条
  • [1] Low-dose enzyme replacement therapy for Gaucher disease: a case report
    Alegra, T.
    Krug, B.
    Oliveira, F.
    Pinto, L. L. C.
    Wanderley, H. Y.
    Todeschini, L. A.
    Picon, P.
    Schwartz, I. V.
    ACTA PAEDIATRICA, 2008, 97 : 116 - 116
  • [2] Effect of low-dose enzyme replacement therapy on bones in Gaucher disease patients with severe skeletal involvement
    Elstein, D
    HadasHalpern, I
    Itzchaki, M
    Lahad, A
    Abrahamov, A
    Zimran, A
    BLOOD CELLS MOLECULES AND DISEASES, 1996, 22 (11) : 104 - 111
  • [3] Effect of low-dose enzyme replacement therapy on bones in Gaucher disease patients with severe skeletal involvement - Commentary
    Beutler, E
    BLOOD CELLS MOLECULES AND DISEASES, 1996, 22 (11) : 113 - 114
  • [4] Low-dose low-frequency imiglucerase as a starting regimen of enzyme replacement therapy for patients with type I Gaucher disease
    Elstein, D
    Abrahamov, A
    Hadas-Halpern, I
    Meyer, A
    Zimran, A
    QJM-MONTHLY JOURNAL OF THE ASSOCIATION OF PHYSICIANS, 1998, 91 (07): : 483 - 488
  • [5] LOW-DOSE ENZYME REPLACEMENT THERAPY FOR PATIENTS WITH GAUCHER DISEASE - EFFECTS OF AGE, SEX, GENOTYPE AND SPLENECTOMY ON RESPONSE TO TREATMENT IN 29 PATIENTS
    ZIMRAN, A
    KANNAI, R
    COHEN, Y
    ZEVIN, S
    HADASHALPERN, I
    ABRAHAMOV, A
    BLOOD, 1993, 82 (10) : A33 - A33
  • [6] Low dose enzyme replacement therapy in paediatric type 1 Gaucher's disease
    Bembi, B
    Donda, MG
    Martini, C
    Zanatta, M
    Boscolo, R
    Katouzian, F
    Ciana, G
    RIVISTA ITALIANA DI PEDIATRIA-ITALIAN JOURNAL OF PEDIATRICS, 1998, 24 (01): : 93 - 98
  • [7] LOW-DOSE HIGH-FREQUENCY ENZYME REPLACEMENT THERAPY FOR VERY YOUNG-CHILDREN WITH SEVERE GAUCHER DISEASE
    ZIMRAN, A
    ZEVIN, S
    LEVYLAHAD, E
    ABRAHAMOV, A
    BRITISH JOURNAL OF HAEMATOLOGY, 1993, 85 (04) : 783 - 786
  • [8] EFFECTIVENESS OF LOW-DOSE ENZYME REPLACEMENT THERAPY IN GAUCHERS-DISEASE
    BRADY, RO
    DAMBROSIA, JM
    BARTON, NW
    CLINICAL RESEARCH, 1992, 40 (02): : A144 - A144
  • [9] Enzyme replacement therapy for mild patients with Gaucher disease
    Zimran, Ari
    Ilan, Yaron
    Elstein, Deborah
    AMERICAN JOURNAL OF HEMATOLOGY, 2009, 84 (04) : 202 - 204
  • [10] Enzyme replacement therapy for Gaucher disease
    Charrow, Joel
    EXPERT OPINION ON BIOLOGICAL THERAPY, 2009, 9 (01) : 121 - 131
12345