Pre-sarcopenia in patients undergoing hemodialysis: Prevalence and association with biochemical parameters

Background & Aims: Albumin and C reactive protein (CRP) concentrations are associated with the loss of lean body mass in the elderly. However, it remains to be ascertained whether these parameters are associated with pre-sarcopenia of chronic renal failure adult's patients undergoing replacement therapy. Therefore, we aimed to investigate the prevalence of pre-sarcopenia and it association with serum albumin and CRP concentrations in adult patients. Methods: A cross-sectional study was conducted enrolling hemodialysis patients. Body weight, body mass index (BMI), and arm, thigh and calf circumferences were assessed using the inelastic tape; handgrip strength using a dynamometer; and body fat mass and appendicular lean mass (ALM) using the DXA. The classification of pre-sarcopenia was obtained by ALM values. Results: From sixty-two patients, 35.5% were diagnosed with pre-sarcopenia. Logistic regression analysis revealed no show association between pre-sarcopenia (absence or presence) with serum CRP or albumin concentrations in both models, crude or adjusted by body fat mass. Conclusions: Approximately one-third of patients undergoing replacement therapy presented presarcopenia, but no association with serum albumin and CRP concentrations were found. (c) 2018 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.