SYNTHESIS AND ANTIVIRAL ACTIVITIES OF CARBOCYCLIC OXETANOCIN ANALOGS

被引：44

作者：

MARUYAMA, T

SATO, Y

HORII, T

SHIOTA, H

NITTA, K

SHIRASAKA, T

MITSUYA, H

HONJO, M

机构：

[1] TOKUSHIMA BUNRI UNIV, FAC PHARMACEUT SCI, YAMASHIRO, TOKUSHIMA 770, JAPAN

[2] UNIV TOKUSHIMA, SCH MED, TOKUSHIMA 770, JAPAN

[3] NCI, CLIN ONCOL PROGRAM, BETHESDA, MD 20892 USA

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1990年 / 38卷 / 10期

关键词：

adenine; antiviral activity; carbocyclic nucleoside; carbocyclic oxetanocin; cyclobutane; guanine; herpes simplex virus; human immunodeficiency virus; oxetanocin;

D O I：

10.1248/cpb.38.2719

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

9-Cyclobutyladenine (4a), cis- and trans-9- [3-(hydroxymethyl)cyclobutyl] adenine (4b) and 9-[3,3-bis(hydroxy-methyl)cyclobutyl]adenine(4d) were prepared from the corresponding cyclobutylamine derivatives (1a, lb and Id). Guanine congeners (9a, cis- and trans-9b and 9d) and carbocyclic oxetanocin G (\\\\\\\\\\\\\\\\2 ‘-trans-9f) were also prepared. Carbocyclic oxetanocin A(l ‘,2’-tra/i5-4f), the preparation of which we have already published, and G were found to be active against herpes simplex virus (type 1 and 2) in vitro, while cis-4b and civ-9b showed an in vitro antiretroviral activity against human immunodeficiency virus (type 1). © 1990, The Pharmaceutical Society of Japan. All rights reserved.

引用

页码：2719 / 2725

页数：7

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