CHANGES IN MEAN TELOMERE LENGTH IN BASAL-CELL CARCINOMAS OF THE SKIN

被引:17
|
作者
WAINWRIGHT, LJ
MIDDLETON, PG
REES, JL
机构
[1] UNIV NEWCASTLE UPON TYNE,ROYAL VICTORIA INFIRM,DEPT DERMATOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
[2] UNIV NEWCASTLE UPON TYNE,ROYAL VICTORIA INFIRM,DEPT HAEMATOL,NEWCASTLE TYNE NE1 4LP,TYNE & WEAR,ENGLAND
来源
GENES CHROMOSOMES & CANCER | 1995年 / 12卷 / 01期
关键词
D O I
10.1002/gcc.2870120108
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Human telomeres consist of arrays of the sequence TTAGGG up to 15-20 kb in length, which are essential For the maintenance of normal chromosomal stability. It has been suggested that genomic instability observed in tumours may be due to loss of telomere sequences, Somatic cells that are dividing continuously appear to progressively lose telomere sequences, and it would therefore be anticipated char cell type specific differences in mean telomere length may exist within an individual. Previous reports have suggested that mean telomere length may be different in human neoplasia when compared to control. Basal cell carcinomas are epidermal derived rumours and in order therefore to make valid cell type specific comparisons we have measured mean telomere length in 20 basal cell carcinomas as weil as in both adjacent epidermis and dermis. Mean telomere length was significantly reduced in epidermis in comparison with dermis, from clinically normal skin immediately adjacent to the rumours (mean difference 2.5 kb). This result is not related to the presence of the tumour as similar results were obtained from skin samples of healthy volunteers. Basal cell carcinomas showed increased mean telomere length in 13/20 samples in comparison with matched epidermis (mean difference 3.1 kb), whereas in 7/20 mean telomere length was reduced (mean difference 2.2 kb). These results showing chat mean telomere length varies from cell type to cell type underpin the importance of performing cell type specific controls when assessing changes in tumour telomeres. (C) 1995 Wiley-Liss, Inc.
引用
收藏
页码:45 / 49
页数:5
相关论文
共 50 条
  • [1] KERATIN PHENOTYPES IN BASAL-CELL CARCINOMAS OF THE SKIN
    TSUBURA, A
    OYAIZU, T
    FUJITA, Y
    ASADA, M
    HILGERS, J
    MORII, S
    INTERNATIONAL JOURNAL OF ONCOLOGY, 1993, 2 (03) : 431 - 435
  • [2] BASAL-CELL CARCINOMAS AND BASAL-CELL CARCINOMA-LIKE CHANGES OVERLYING DERMATOFIBROMAS
    GOETTE, DK
    HELWIG, EB
    ARCHIVES OF DERMATOLOGY, 1975, 111 (05) : 589 - 592
  • [3] BASAL-CELL CARCINOMAS
    PUISSANT, A
    NOURY, JY
    DUPERRATNOURY, G
    REVUE DU PRATICIEN, 1982, 32 (31): : 2095 - &
  • [4] BASAL-CELL CARCINOMAS
    SRENGER, Z
    STIGLMAYER, N
    KLINISCHE MONATSBLATTER FUR AUGENHEILKUNDE, 1983, 183 (05) : 420 - 421
  • [5] FIBRONECTIN IN BASAL-CELL AND SQUAMOUS-CELL CARCINOMAS OF SKIN
    HILL, AJ
    TALBOT, IC
    JOURNAL OF PATHOLOGY, 1982, 138 (01): : 77 - 78
  • [6] BASAL-CELL CARCINOMAS
    DZUBOW, LM
    PLASTIC AND RECONSTRUCTIVE SURGERY, 1986, 77 (01) : 162 - 163
  • [7] MULTIPLE BASAL-CELL CARCINOMAS OF SKIN - TREATMENT WITH CURETTAGE
    REYMANN, F
    ARCHIVES OF DERMATOLOGY, 1975, 111 (07) : 877 - 879
  • [8] A MANAGEMENT APPROACH TO INCOMPLETELY EXCISED BASAL-CELL CARCINOMAS OF SKIN
    LIU, FF
    MAKI, E
    WARDE, P
    PAYNE, D
    FITZPATRICK, P
    INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS, 1991, 20 (03): : 423 - 428
  • [9] INVOLUCRIN IN SQUAMOUS AND BASAL-CELL CARCINOMAS OF THE SKIN - AN IMMUNOHISTOCHEMICAL STUDY
    SAID, JW
    SASSOON, AF
    SHINTAKU, IP
    BANKSSCHLEGEL, S
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1984, 82 (05) : 449 - 452
  • [10] BASAL-CELL CARCINOMAS OF THE EYELIDS
    BONVALLOT, T
    RAULO, Y
    ZELLER, J
    BARUCH, J
    ANNALES DE DERMATOLOGIE ET DE VENEREOLOGIE, 1988, 115 (6-7): : 669 - 678