INTERLEUKIN-1-BETA (IL-1-BETA) INDUCES TRANSFORMING GROWTH FACTOR-BETA(1) (TGF-BETA(1)) PRODUCTION BY RAT AORTIC SMOOTH-MUSCLE CELLS

被引：37
|
作者：
YUE, TL
WANG, XK
OLSON, B
FEUERSTEIN, G
机构：
[1] Department of Cardiovascular Pharmacology, SmithKline Beecham Pharmaceuticals, King of Prussia
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1994年 / 204卷 / 03期
关键词：
D O I：
10.1006/bbrc.1994.2588
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
In cultured rat aortic smooth muscle cells (RASMCs) IL-1 beta induced TGF-beta(1) mRNA expression, which was concentration (10 pM-10 nM)- and time (2-48 h)-dependent, and sensitive to cycloheximide. The maximal increase in TGF-beta(1) mRNA was 4.5 times the basal level at 10 nM of IL-1 beta. A parallel increase In TGF-beta(1) protein in the culture medium of IL-1 beta-stimulated RASMCs was also observed. A detectable level of TGF-beta(1) was found 8 h after stimulation and a plateau was reached at 72 h with a maximal increase of 5-fold and was inhibited by IL-1 receptor antagonist (IL-1ra). Our data demonstrate for the first time that IL-1 beta is a potent inducer of TGF-beta(1) synthesis and release in vascular smooth muscle cells. (C) 1994 Academic Press, Inc.
引用
收藏
页码：1186 / 1192
页数：7
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