Microbiological and immunological characteristics of a lethal pulmonary Aspergillus niger infection in a non-neutropenic patient

被引：6

作者：

Workum, Jessica D. ^{[1
,2
]}

de Jong, Suzanne W. ^{[3
]}

Gresnigt, Mark S. ^{[1
]}

Becker, Katharina L. ^{[1
]}

Pickkers, Peter ^{[2
]}

van de Veerdonk, Frank L. ^{[1
]}

Heijdra, Yvonne F. ^{[3
]}

Kolwijck, Eva ^{[4
]}

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Internal Med, Nijmegen, Netherlands

[2] Radboud Univ Nijmegen, Med Ctr, Dept Intens Care Med, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Pulmonol, Nijmegen, Netherlands

[4] Radboud Univ Nijmegen, Med Ctr, Dept Med Microbiol, Nijmegen, Netherlands

来源：

MEDICAL MYCOLOGY CASE REPORTS | 2018年 / 21卷

关键词：

Invasive pulmonary aspergillosis; Aspergillus niger; Immune system; Intensive care unit; Oxalate crystal;

D O I：

10.1016/j.mmcr.2018.03.002

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Invasive pulmonary aspergillosis is increasingly described in non-neutropenic patients, such as patients with COPD receiving corticosteroids and the critically ill. Here, we present a case of a lethal pulmonary Aspergillus niger infection in a COPD patient. Immunological tests showed an impaired innate and adaptive immune response to Aspergillus. A history of COPD, unresponsiveness to antibiotics and especially a suggestive CT-scan should trigger the clinician to consider diseases caused by Aspergillus.

引用

页码：4 / 7

页数：4

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