THE CHROMATIN-ASSOCIATED PROTEIN H-NS

被引：107
|
作者：
USSERY, DW
HINTON, JCD
JORDI, BJAM
GRANUM, PE
SEIRAFI, A
STEPHEN, RJ
TUPPER, AE
BERRIDGE, G
SIDEBOTHAM, JM
HIGGINS, CF
机构：
[1] UNIV OXFORD,JOHN RADCLIFFE HOSP,INST MOLEC MED,IMPERIAL CANC RES FUND LABS,OXFORD OX3 9DU,ENGLAND
[2] UNIV OXFORD,JOHN RADCLIFFE HOSP,NUFFIELD DEPT CLIN BIOCHEM,OXFORD OX3 9DU,ENGLAND
来源：
BIOCHIMIE | 1994年 / 76卷 / 10-11期
关键词：
H-NS; BACTERIAL CHROMATIN; BISTONE-LIKE PROTEIN; NUCLEOID; GENE EXPRESSION; DNA SUPERCOILING;
D O I：
10.1016/0300-9084(94)90022-1
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
H-NS is a major component of chromatin in enteric bacteria. H-NS plays a structural role in organising the chromosome, and influences DNA rearrangements as well as the expression of many genes. The biochemical and functional characteristics of H-NS are distinct from those of 'typical' DNA-binding proteins and much remains to be learned about the mechanism(s) by which H-NS acts. In this article we review our current understanding of the role of H-NS, and describe possible models by which H-NS might influence DNA structure and gene expression.
引用
收藏
页码：968 / 980
页数：13
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