EFFECTS OF THE 5HT1A AGONIST, 8-OH-DPAT, ON OPERANT FOOD-INTAKE IN NON-DEPRIVED RATS

被引：33
|
作者：
EBENEZER, IS
机构：
[1] Neuropharmacology Research Group, School of Pharmacy and Biomedical Sciences, Portsmouth Polytechnic, Portsmouth, Hampshire
来源：
NEUROREPORT | 1992年 / 3卷 / 01期
关键词：
8-OH-DPAT; 5-HT; OPERANT BEHAVIOR; FOOD INTAKE; HYPERPHAGIA; 5HT1A RECEPTORS; STEREOTYPY; RATS;
D O I：
10.1097/00001756-199201000-00016
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
THE aim of the present study was to determine whether the hyperphagia produced by systemic administration of 8-OH-DPAT is independent of drug-induced chewing or gnawing behaviour. The effects of 8-OH-DPAT (15.625-500-mu-g kg-1, s.c.) were therefore investigated on operant food intake in non-deprived rats. Low doses (i.e. 15.625-62.5-mu-g kg-1) increased operant food intake. Drug-induced stereotypy disrupted operant responding at the higher doses. The results thus suggest that 8-OH-DPAT-induced hyperphagia is independent of chewing or gnawing behaviour.
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页码：62 / 64
页数：3
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