HIGHLY WATER-SOLUBLE TAXOL DERIVATIVES - 2'-POLYETHYLENEGLYCOL ESTERS AS POTENTIAL PRODRUGS

被引：68
|
作者：
GREENWALD, RB
PENDRI, A
BOLIKAL, D
GILBERT, CW
机构：
[1] Enzon Inc., Piscataway
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 20期
关键词：
D O I：
10.1016/S0960-894X(01)80411-X
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
2' and 7-polyethylene glycol esters of taxol were prepared and found to be essentially water soluble. The rates of hydrolysis of these compounds were measured under neutral, acidic and physiological (basic) conditions. The half-lives of O and N substituted 2'-esters are short enough to permit their use as prodrugs.
引用
收藏
页码：2465 / 2470
页数：6
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