Expression of p16 in Conjunctival Intraepithelial Neoplasia Does Not Correlate with HPV-Infection

被引：20

作者：

Auw-Haedrich, Claudia ^{[1
]}

Martin, Gottfried ^{[1
]}

Spelsberg, Helga ^{[2
]}

Sundmacher, Rainer ^{[3
]}

Freudenberg, Nikolaus ^{[4
]}

Maier, Philip ^{[1
]}

Reinhard, Thomas ^{[1
]}

机构：

[1] Albert Ludwigs Univ, Eye Hosp, Killianstr 5, D-79106 Freiburg, Germany

[2] Clin Pallas Otten, Eye Ctr, Otten, Switzerland

[3] Heinrich Heine Univ, Eye Hosp, D-40125 Dusseldorf, Germany

[4] Albert Ludwigs Univ, Inst Pathol, D-79106 Freiburg, Germany

来源：

OPEN OPHTHALMOLOGY JOURNAL | 2008年 / 2卷

关键词：

p16; conjunctival intraepithelial neoplasia; HPV;

D O I：

10.2174/1874364100802010048

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

The aim of our study was to identify the frequency of expression of p16(INK4a) (CDKN2A) and HPV (human papilloma virus) in different grades of conjunctival intraepithelial neoplasia (CIN). Twelve specimens including CIN I (2), II (3), III (5), and CIN with beginning invasion (2), as well as 15 control specimens, were stained with antibodies against p16(INK4a) and MIB1. The presence of HPV was examined by PCR. p16 as well as MIB1 were significantly elevated in CIN compared to control specimens (p<0.01) without correlation with the differentiation grade. Only two cases with CIN grade 3 contained HPV 16. As few control specimens also showed increased p16(INK4a) expression, p16(INK4a) seems not to be a very reliable marker for the exact determination of CIN. It could serve as an additional diagnostic tool besides the morphological characterization. Our study suggested that p16(INK4a) elevation is not associated with HPV infection.

引用

页码：48 / 56

页数：9

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